Receptors and sequences¶
This video demonstrates how to use the receptor pages.
- By moving the pointer over residues in the sequence viewer, more information can be displayed.
- Snake and Helix box plots can be custom colored and downloaded.
- A summary of available mutant data is displayed, and a link provided for further analysis.
- Available structure information is listed.
- Look up the receptor page for the beta1-adrenoceptor. How many mutations are there available?
- Look up the receptor page for your favorite GPCR. Is there any data available?
Structure-based sequence alignments¶
This video demonstrates how to build a structure-based sequence alignment.
- Any combination of receptors and/or receptor families can be selected.
- It is possible to limit the alignment to a particular part of the sequence, e.g. TM6.
- By moving the pointer over residues in the alignment, more information can be displayed.
- A consensus sequence (color coded by conservation) is displayed below the alignment.
- Statistics on residue and residue property conservation is displayed below the consensus sequence.
- Create an alignment of TM5 for all Class A peptide receptors. How well conserved is position 5.50?
This video demonstrates how to perform similarity search with a reference receptor.
- Only one receptor can be selected as reference, and the other selected receptors will be compared to the reference.
- It is possible to limit the search to a particular part of the sequence, e.g. TM6.
- In the resulting sequence alignment, the sequences are ranked by similarity to the reference, and their similarity scores are shown to the right of the receptor name.
- Look up the similarity of the FFA1 receptor against Class A lipid receptors using the 7TMs. Which receptor is most similar?